N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide

Base Information

• Chemical Name: N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide
• CAS No.: 1105634-61-4
• Molecular Formula: C₂₀H₁₆Cl₂N₂O₄
• Molecular Weight: 419.264
• Mol file: 1105634-61-4.mol

Synonyms:N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide

Chemical Property of N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide

There total 1 articles about N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.7%

5-(3-chloro-4-isopropoxyphenyl)isoxazole-3-carboxylic acid (1105635-32-2) + 4-amino-3-chlorobenzaldehyde (93359-88-7) → N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide (1105634-61-4)

Guidance literature:

With pyridine; trichlorophosphate; at -15 ℃; for 1h;

Reference yield:

DL-3-aminoisobutyric acid (10569-72-9) + N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide (1105634-61-4) → C24H25Cl2N3O5 (1105628-75-8)

Guidance literature:

DL-3-aminoisobutyric acid; N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide; With acetic acid; In methanol; dichloromethane; at 40 ℃;

With sodium cyanoborohydride; In methanol; dichloromethane; at 20 ℃; for 8h;

Reference yield:

N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide (1105634-61-4) + 3-azetidinecarboxylic acid (36476-78-5) → C24H23Cl2N3O5 (1105628-69-0)

Guidance literature:

N-(2-chloro-4-formylphenyl)-5-(3-chloro-4-isopropoxyphenyl)-isoxazole-3-carboxamide; 3-azetidinecarboxylic acid; With acetic acid; In methanol; 1,2-dichloro-ethane; at 40 ℃; for 4h;

With sodium cyanoborohydride; In methanol; 1,2-dichloro-ethane; at 20 ℃;

upstream raw materials:

5-(3-chloro-4-isopropoxyphenyl)isoxazole-3-carboxylic acid

4-amino-3-chlorobenzaldehyde

Downstream raw materials:

C₂₄H₂₅Cl₂N₃O₅

C₂₄H₂₃Cl₂N₃O₅