(1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide

Base Information

• Chemical Name: (1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide
• CAS No.: 913962-67-1
• Molecular Formula: C₂₃H₃₁NO₂
• Molecular Weight: 353.505
• Mol file: 913962-67-1.mol

Synonyms:(1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide

Chemical Property of (1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide

There total 2 articles about (1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert.-butyl lithium (594-19-4) + E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-phenylprop-2-enamide (678991-36-1) → (1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide (913962-67-1) + (1'S,2'S,3R)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide (913962-68-2)

Guidance literature:

With lithium chloride; In tetrahydrofuran; hexane; at -105 - 20 ℃;

DOI:10.1021/jo061205e

Reference yield: 84.0%

phenyllithium (591-51-5) + E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide (678991-35-0) → (1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide (913962-67-1) + (1'S,2'S,3R)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide (913962-68-2)

Guidance literature:

With lithium chloride; In tetrahydrofuran; hexane; at -105 - 20 ℃;

DOI:10.1021/jo061205e

Reference yield: 80.0%

(1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide (913962-67-1) → (S)-(-)-4,4-dimethyl-3-phenyl-1-pentanol (137542-89-3)

Guidance literature:

With n-butyllithium; ammonia borane; diisopropylamine; In tetrahydrofuran; hexane; at 20 ℃; for 2h;

DOI:10.1021/jo061205e

upstream raw materials:

tert.-butyl lithium

E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-phenylprop-2-enamide

phenyllithium

E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide

Downstream raw materials:

(S)-(-)-4,4-dimethyl-3-phenyl-1-pentanol

(S)-4,4-dimethyl-3-phenylpentanoic acid