Dimethyl (3-chloropropionamido)malonate

Base Information

Chemical Name:Dimethyl (3-chloropropionamido)malonate
CAS No.:68641-22-5
Molecular Formula:C₂₁H₂₂ClNO₆
Molecular Weight:419.862
Hs Code.:

Dimethyl <p-(Benzyloxy)phenyl>(3-chloropropionamido)malonate

Synonyms:Dimethyl (3-chloropropionamido)malonate

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Chemical Property of Dimethyl (3-chloropropionamido)malonate

Chemical Property:

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Technology Process of Dimethyl (3-chloropropionamido)malonate

There total 5 articles about Dimethyl (3-chloropropionamido)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: Dimethyl Aminomalonate Hydrochloride

: 625-36-5
2-chloropropionyl chloride

: 68641-22-5
Dimethyl (3-chloropropionamido)malonate

Guidance literature:: With N,N-dimethyl-aniline; In dichloromethane; 1.) 0 deg C, 15 min, 2.) room temp., 4h;
DOI:10.1021/jo00328a002

Reference yield:

: 68641-16-7
(4-benzyloxy-phenyl)-acetic acid methyl ester

: 68641-22-5
Dimethyl (3-chloropropionamido)malonate

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / NaH / diethyl ether; methanol / 24 h / Ambient temperature

2: 1.) NaH, HMPA, 2.) p-Toluenesulfonyl azide / 1.) THF, room temp., 2h, 2.) reflux, 2h

3: 1.) Zn, 90percent CH₃COOH, 2.) HCl(gas) / 1.) room temp., 2h, 2.) ether

4: 86 percent / N,N-dimethylaniline / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temp., 4h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; 4-toluenesulfonyl azide; sodium hydride; acetic acid; N,N-dimethyl-aniline; zinc; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00328a002

Reference yield:

: 68641-17-8
4-benzyloxyphenyl malonic acid dimethylester

: 68641-22-5
Dimethyl (3-chloropropionamido)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH, HMPA, 2.) p-Toluenesulfonyl azide / 1.) THF, room temp., 2h, 2.) reflux, 2h

2: 1.) Zn, 90percent CH₃COOH, 2.) HCl(gas) / 1.) room temp., 2h, 2.) ether

3: 86 percent / N,N-dimethylaniline / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temp., 4h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; 4-toluenesulfonyl azide; sodium hydride; acetic acid; N,N-dimethyl-aniline; zinc; In dichloromethane;
DOI:10.1021/jo00328a002