4β-2-(N-benzoyl-4''-carbomethoxyindol-3''-yl)glyoxylamido-4-deoxypodophyllotoxin

Base Information

• Chemical Name: 4β-2-(N-benzoyl-4''-carbomethoxyindol-3''-yl)glyoxylamido-4-deoxypodophyllotoxin
• CAS No.: 1316852-89-7
• Molecular Formula: C₄₁H₃₄N₂O₁₂
• Molecular Weight: 746.727
• Mol file: 1316852-89-7.mol

Synonyms:4β-2-(N-benzoyl-4''-carbomethoxyindol-3''-yl)glyoxylamido-4-deoxypodophyllotoxin

Chemical Property of 4β-2-(N-benzoyl-4''-carbomethoxyindol-3''-yl)glyoxylamido-4-deoxypodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4β-2-(N-benzoyl-4''-carbomethoxyindol-3''-yl)glyoxylamido-4-deoxypodophyllotoxin

There total 6 articles about 4β-2-(N-benzoyl-4''-carbomethoxyindol-3''-yl)glyoxylamido-4-deoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C34H30N2O11 (1316852-84-2) + benzoyl chloride (98-88-4) → 4β-2-(N-benzoyl-4''-carbomethoxyindol-3''-yl)glyoxylamido-4-deoxypodophyllotoxin (1316852-89-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1080/10286020.2011.568941

Reference yield:

methyl 1H-indole-4-carboxylate (39830-66-5) → 4β-2-(N-benzoyl-4''-carbomethoxyindol-3''-yl)glyoxylamido-4-deoxypodophyllotoxin (1316852-89-7)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 0 - 20 °C

2: dmap; triethylamine / dichloromethane / 12 h / 20 °C

3: dmap; triethylamine / dichloromethane / 6 h / 20 °C

With dmap; triethylamine; In diethyl ether; dichloromethane; 1: Friedel-Crafts acylation;

DOI:10.1080/10286020.2011.568941

Reference yield:

C12H8ClNO4 (1316852-91-1) → 4β-2-(N-benzoyl-4''-carbomethoxyindol-3''-yl)glyoxylamido-4-deoxypodophyllotoxin (1316852-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

2: dmap; triethylamine / dichloromethane / 6 h / 20 °C

With dmap; triethylamine; In dichloromethane;

DOI:10.1080/10286020.2011.568941

upstream raw materials:

C₃₄H₃₀N₂O₁₁

benzoyl chloride

C₁₂H₈ClNO₄

methyl 1H-indole-4-carboxylate