tert-butyl 4-(2-(N-benzyl-2,2-divinylcyclopropanecarboxamido)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(N-benzyl-2,2-divinylcyclopropanecarboxamido)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate
CAS No.:1312331-07-9
Molecular Formula:C₃₀H₃₄N₂O₃
Molecular Weight:470.612
Hs Code.:

Synonyms:tert-butyl 4-(2-(N-benzyl-2,2-divinylcyclopropanecarboxamido)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(N-benzyl-2,2-divinylcyclopropanecarboxamido)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

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Technology Process of tert-butyl 4-(2-(N-benzyl-2,2-divinylcyclopropanecarboxamido)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

There total 11 articles about tert-butyl 4-(2-(N-benzyl-2,2-divinylcyclopropanecarboxamido)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: C₈H₉ClO

: 1312331-06-8
tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

: 1312331-07-9
tert-butyl 4-(2-(N-benzyl-2,2-divinylcyclopropanecarboxamido)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja2042854

Reference yield:

: trans-tert-butyl 3-iodo-2-methoxypyrrolidine-1-carboxylate

: 1312331-07-9
tert-butyl 4-(2-(N-benzyl-2,2-divinylcyclopropanecarboxamido)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: citric acid / toluene / 6 h / Inert atmosphere; Reflux

2: barium hydroxide octahydrate; palladium diacetate; CyJohnPhos / 2 h / 60 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 5 h / 20 °C / Inert atmosphere

4: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; barium hydroxide octahydrate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; citric acid; CyJohnPhos; In dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ja2042854

Reference yield:

: 1042701-07-4
tert-butyl 4-(2-aminophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

: 1312331-07-9
tert-butyl 4-(2-(N-benzyl-2,2-divinylcyclopropanecarboxamido)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 5 h / 20 °C / Inert atmosphere

2: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ja2042854