tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate
CAS No.:1312331-06-8
Molecular Formula:C₂₂H₂₆N₂O₂
Molecular Weight:350.461
Hs Code.:

Synonyms:tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

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Technology Process of tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

There total 5 articles about tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1042701-07-4
tert-butyl 4-(2-aminophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

: 100-52-7
benzaldehyde

: 1312331-06-8
tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ja2042854

Reference yield:

: trans-tert-butyl 3-iodo-2-methoxypyrrolidine-1-carboxylate

: 1312331-06-8
tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: citric acid / toluene / 6 h / Inert atmosphere; Reflux

2: barium hydroxide octahydrate; palladium diacetate; CyJohnPhos / 2 h / 60 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 5 h / 20 °C / Inert atmosphere

With barium hydroxide octahydrate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; citric acid; CyJohnPhos; In 1,2-dichloro-ethane; toluene;
DOI:10.1021/ja2042854

Reference yield:

: 1196146-93-6
tert-butyl 4-iodo-2,3-dihydro-1H-pyrrole-1-carboxylate

: 1312331-06-8
tert-butyl 4-(2-(benzylamino)phenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: barium hydroxide octahydrate; palladium diacetate; CyJohnPhos / 2 h / 60 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 5 h / 20 °C / Inert atmosphere

With barium hydroxide octahydrate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; CyJohnPhos; In 1,2-dichloro-ethane;
DOI:10.1021/ja2042854