N-CARBAMYL-L-TRYPTOPHAN

Base Information

• Chemical Name: N-CARBAMYL-L-TRYPTOPHAN
• CAS No.: 89595-64-2
• Molecular Formula: C12H13 N3 O3
• Molecular Weight: 247.254
• Hs Code.: 2933990090
• Mol file: 89595-64-2.mol

Synonyms:N-Carbamoyl-L-tryptophan

Chemical Property of N-CARBAMYL-L-TRYPTOPHAN

Chemical Property:

• Melting Point: 198 °C
• Boiling Point: 538.4±50.0 °C(Predicted)
• PKA: 3.88±0.10(Predicted)
• PSA: 109.20000
• Density: 1.434±0.06 g/cm3(Predicted)
• LogP: 1.73660
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

(2S)-2-[(AMINOCARBONYL)AMINO]-3-(1H-INDOL-3-YL)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-CARBAMYL-L-TRYPTOPHAN

There total 4 articles about N-CARBAMYL-L-TRYPTOPHAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

urea (57-13-6) + L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) → N-carbamoyl-L-tryptophan (89595-64-2)

Guidance literature:

With sodium hydroxide; for 0.0666667h; microwave irradiation;

DOI:10.1080/00397910701317068

Reference yield: 44.0%

N-carbamoyl-(D/L)-tryptophane amide → N-carbamoyl-L-tryptophan (89595-64-2)

Guidance literature:

With sodium hydroxide; phosphate buffer; Chirazyme P₁; at 22 ℃; for 24h; pH=7.5;

DOI:10.1016/S0040-4039(03)00746-9

Reference yield:

DL-5-indolylmethylhydantoin (108605-53-4) → N-carbamoyl-L-tryptophan (89595-64-2) + N-carbamyl-D-tryptophan (54896-75-2)

Guidance literature:

With Tris-HCl buffer; Flavobacterium sp. AJ-3912; In various solvent(s); at 30 ℃; for 2h;

upstream raw materials:

urea

L-Tryptophan

DL-5-indolylmethylhydantoin

potassium cyanate

Downstream raw materials:

L-tryptophan hydantoin

L-Tryptophan

Refernces

• 1、 Patching, Simon G.. "Efficient syntheses of 13C- and 14C-labelled 5-benzyl and 5-indolylmethyl L-hydantoins". experimental part. p. 110 - 114. Retrieved 2011/10/07.
• 2、 Trauthwein, Harald,May, Oliver,Dingerdissen, Uwe,Buchholz, Stefan,Drauz, Karlheinz. "A new biocatalytic route to enantiopure N-carbamoyl amino acids by fast enzyme screening". . p. 3737 - 3739. Retrieved 2007/10/03.