(2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

Base Information

Chemical Name:(2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol
CAS No.:316790-27-9
Molecular Formula:C₅₅H₇₀O₁₅
Molecular Weight:971.152
Hs Code.:

(2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

Synonyms:(2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

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Chemical Property of (2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

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Technology Process of (2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

There total 10 articles about (2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 316790-26-8
Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

: 316790-27-9
(2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 20h;
DOI:10.1021/jo0012952

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 316790-27-9
(2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 76 percent / (n-Bu)4NI / dimethylformamide / 0 h / 20 °C

2.1: dimethyldioxirane / CH₂Cl₂; acetone / -25 °C

3.1: 95 mg / ZnCl₂ / tetrahydrofuran / 14 h / 20 °C

4.1: 89 percent / AgOTf; 2,6-di-tert-butylpyridine; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / -5 °C

5.1: MeONa / methanol / 20 h / 20 °C

With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; sodium methylate; silver trifluoromethanesulfonate; 3,3-dimethyldioxirane; sodium hydride; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 4.1: Koenigs-Knorr reaction;
DOI:10.1021/jo0012952

Reference yield:

: 13265-84-4
D-glucal

: 316790-27-9
(2R,4aR,6S,7R,8R,8aS)-6-[(2R,3R,4S,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 76 percent / (n-Bu)4NI / dimethylformamide / 0 h / 20 °C

2.1: dimethyldioxirane / CH₂Cl₂; acetone / -25 °C

3.1: 95 mg / ZnCl₂ / tetrahydrofuran / 14 h / 20 °C

4.1: 89 percent / AgOTf; 2,6-di-tert-butylpyridine; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / -5 °C

5.1: MeONa / methanol / 20 h / 20 °C

With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; sodium methylate; silver trifluoromethanesulfonate; 3,3-dimethyldioxirane; sodium hydride; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 4.1: Koenigs-Knorr reaction;
DOI:10.1021/jo0012952