N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N⁽⁴⁾-benzoylcytosin-1-yl)-(2'R)-proline diphenylmethyl ester

Base Information

• Chemical Name: N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N⁽⁴⁾-benzoylcytosin-1-yl)-(2'R)-proline diphenylmethyl ester
• CAS No.: 1286700-53-5
• Molecular Formula: C₄₆H₄₁N₅O₆
• Molecular Weight: 759.861

Synonyms:N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N⁽⁴⁾-benzoylcytosin-1-yl)-(2'R)-proline diphenylmethyl ester

Chemical Property of N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N⁽⁴⁾-benzoylcytosin-1-yl)-(2'R)-proline diphenylmethyl ester

Chemical Property:

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Technology Process of N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N⁽⁴⁾-benzoylcytosin-1-yl)-(2'R)-proline diphenylmethyl ester

There total 4 articles about N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N⁽⁴⁾-benzoylcytosin-1-yl)-(2'R)-proline diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H8O3S*C29H26N4O4 + (9H-fluoren-9-yl)methyl(2-oxoethyl)carbamate (156939-62-7) → N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N(4)-benzoylcytosin-1-yl)-(2'R)-proline diphenylmethyl ester (1286700-53-5)

Guidance literature:

With sodium acetate; sodium cyanoborohydride; In methanol; at 30 ℃; for 1h;

DOI:10.1080/15257770.2010.547839

Reference yield:

(+/-)-N-fluorenylmethoxycarbonyl-3-amino-1,2-propanediol (167700-44-9) → N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N(4)-benzoylcytosin-1-yl)-(2'R)-proline diphenylmethyl ester (1286700-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium periodate / water; acetonitrile / 3 h / 30 °C

2: sodium acetate; sodium cyanoborohydride / methanol / 1 h / 30 °C

With sodium periodate; sodium acetate; sodium cyanoborohydride; In methanol; water; acetonitrile;

DOI:10.1080/15257770.2010.547839

Reference yield:

(2R,4R)-4-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester (189163-59-5) → N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N(4)-benzoylcytosin-1-yl)-(2'R)-proline diphenylmethyl ester (1286700-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 20 °C

2: sodium acetate; sodium cyanoborohydride / methanol / 1 h / 30 °C

With sodium acetate; sodium cyanoborohydride; In methanol; acetonitrile;

DOI:10.1080/15257770.2010.547839

upstream raw materials:

(9H-fluoren-9-yl)methyl(2-oxoethyl)carbamate

(fluorenylmethoxy)carbonyl chloride

(+/-)-N-fluorenylmethoxycarbonyl-3-amino-1,2-propanediol

(2R,4R)-4-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester

Downstream raw materials:

N-2-(N-fluoren-9-ylmethoxycarbonylamino)ethyl-(4'R)-(N⁽⁴⁾-benzoylcytosin-1-yl)-(2'R)-proline

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