Technology Process of 3-benzyloxy-1-(tetrahydro-2H-pyran-2-yl)oxy butane
There total 4 articles about 3-benzyloxy-1-(tetrahydro-2H-pyran-2-yl)oxy butane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(tetrahydro-2H-pyran-2-yl)oxy-2-butanol;
With
tetrabutyl-ammonium chloride; sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
benzyl bromide;
In
N,N-dimethyl-formamide;
for 4h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 76 percent / stannous chloride dihydrate / CHCl3 / 24 h
2.1: 61 percent / CrO3*pyridine / CHCl3 / 0 °C
3.1: Mg / diethyl ether
3.2: 92 percent / diethyl ether / 0.5 h
4.1: NaH; tetra-n-butylammonium chloride / dimethylformamide / 0.5 h / 0 °C
4.2: 87 percent / dimethylformamide / 4 h
With
chromium trioxide-pyridine complex; tetrabutyl-ammonium chloride; sodium hydride; magnesium; tin(ll) chloride;
In
diethyl ether; chloroform; N,N-dimethyl-formamide;
3.1: Grignard reaction / 3.2: Grignard reaction;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Mg / diethyl ether
1.2: 92 percent / diethyl ether / 0.5 h
2.1: NaH; tetra-n-butylammonium chloride / dimethylformamide / 0.5 h / 0 °C
2.2: 87 percent / dimethylformamide / 4 h
With
tetrabutyl-ammonium chloride; sodium hydride; magnesium;
In
diethyl ether; N,N-dimethyl-formamide;
1.1: Grignard reaction / 1.2: Grignard reaction;
