ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate

Base Information

• Chemical Name: ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate
• CAS No.: 1221962-74-8
• Molecular Formula: C₂₀H₁₉Cl₂NO₃
• Molecular Weight: 392.282
• Mol file: 1221962-74-8.mol

Synonyms:ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate

Chemical Property of ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate

There total 3 articles about ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2,3-dihydro-1H-isoindole (127168-76-7) + 2-(4-chlorophenyl)succinic acid 4-monoethylester (1221962-73-7) → ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate (1221962-74-8)

Guidance literature:

2-(4-chlorophenyl)succinic acid 4-monoethylester; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h; Reflux;

5-chloro-2,3-dihydro-1H-isoindole; With triethylamine; In dichloromethane; at 20 ℃; for 1.5h; Cooling with ice;

Reference yield:

5-chloro-2,3-dihydro-1H-isoindole (127168-76-7) + C12H12Cl2O3 → ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate (1221962-74-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

4-chlorophenylacetic Acid (1878-66-6) → ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate (1221962-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Reflux

2.2: 1.5 h / 20 °C / Cooling with ice

With oxalyl dichloride; lithium diisopropyl amide; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

5-chloro-2,3-dihydro-1H-isoindole

4-chlorophenylacetic Acid

2-(4-chlorophenyl)succinic acid 4-monoethylester

Downstream raw materials:

4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoic acid