(6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione

Base Information

Chemical Name:(6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione
CAS No.:852994-80-0
Molecular Formula:C₂₇H₃₄N₂O₄
Molecular Weight:450.578
Hs Code.:

Synonyms:(6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione

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Technology Process of (6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione

There total 4 articles about (6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 852994-82-2
[(2S,5S)-N,N'-bis-(4-methoxybenzyl)-5-isopropyl-3,6-dioxopiperazin-2-yl]-phosphonic acid diethyl ester

: 78-84-2
isobutyraldehyde

: 852994-80-0
(6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1039/b500566c

Reference yield:

: 835596-02-6
(3S,6S)-3-Chloro-6-isopropyl-1,4-bis-(4-methoxy-benzyl)-piperazine-2,5-dione

: 852994-80-0
(6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 72 h / 20 °C

2: 67 percent / NaH / tetrahydrofuran / 2 h / 0 °C

With sodium hydride; In tetrahydrofuran; dichloromethane; 2: Horner-Wadsworth-Emmons reaction;
DOI:10.1039/b500566c

Reference yield:

: 205517-34-6
(3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

: 852994-80-0
(6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: N-fluorobenzenesulfonamide / tetrahydrofuran / 0.5 h / -78 °C

2.1: chlorotrimethylsilane / CH₂Cl₂ / 2 h / 20 °C

3.1: CH₂Cl₂ / 72 h / 20 °C

4.1: 67 percent / NaH / tetrahydrofuran / 2 h / 0 °C

With chloro-trimethyl-silane; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 4.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1039/b500566c