5-[[(4-Methoxyphenyl)methoxy]methyl]-1-methyl-1H-imidazole

Base Information

Chemical Name:5-[[(4-Methoxyphenyl)methoxy]methyl]-1-methyl-1H-imidazole
CAS No.:384821-12-9
Molecular Formula:C₁₃H₁₆N₂O₂
Molecular Weight:232.282
Hs Code.:
DSSTox Substance ID:DTXSID001194226

Synonyms:DTXSID001194226;5-[[(4-Methoxyphenyl)methoxy]methyl]-1-methyl-1H-imidazole;384821-12-9

Suppliers and Price of 5-[[(4-Methoxyphenyl)methoxy]methyl]-1-methyl-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[[(4-Methoxyphenyl)methoxy]methyl]-1-methyl-1H-imidazole

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:232.121177757
Heavy Atom Count:17
Complexity:218

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C=NC=C1COCC2=CC=C(C=C2)OC

Technology Process of 5-[[(4-Methoxyphenyl)methoxy]methyl]-1-methyl-1H-imidazole

There total 2 articles about 5-[[(4-Methoxyphenyl)methoxy]methyl]-1-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 38993-84-9
(1-methyl-1H-imidazol-5-yl)methanol

: 2746-25-0
p-Methoxybenzyl bromide

: 384821-12-9
5-[(4'-methoxyphenyl)methoxymethyl]-1-methyl-1H-imidazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jo010737m

Reference yield:

: 143122-18-3
5-hydroxymethyl-2-mercapto-1-methyl-1H-imidazole

: 384821-12-9
5-[(4'-methoxyphenyl)methoxymethyl]-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / aq. HNO₃; NaNO₂ / 20 °C

2: 61 percent / NaH / dimethylformamide / 20 °C

With nitric acid; sodium hydride; sodium nitrite; In N,N-dimethyl-formamide;
DOI:10.1021/jo010737m

Reference yield: 77.0%

: 79-22-1
methyl chloroformate

: 384821-12-9
5-[(4'-methoxyphenyl)methoxymethyl]-1-methyl-1H-imidazole

: 384821-15-2
tris{5-[(4'-methoxyphenyl)methoxymethyl]-1-methyl-1H-2-imidazolyl}methyl alcohol

Guidance literature:: 5-[(4'-methoxyphenyl)methoxymethyl]-1-methyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 1h;

methyl chloroformate; In tetrahydrofuran; at -78 - 20 ℃; for 24h; Further stages.;
DOI:10.1021/jo010737m