1-(4-methoxyphenyl)-4-methyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pent-1-en-3-ol

Base Information

Chemical Name:1-(4-methoxyphenyl)-4-methyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pent-1-en-3-ol
CAS No.:1346261-54-8
Molecular Formula:C₁₉H₂₉BO₄
Molecular Weight:332.248
Hs Code.:

Synonyms:1-(4-methoxyphenyl)-4-methyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pent-1-en-3-ol

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Chemical Property of 1-(4-methoxyphenyl)-4-methyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pent-1-en-3-ol

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Technology Process of 1-(4-methoxyphenyl)-4-methyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pent-1-en-3-ol

There total 2 articles about 1-(4-methoxyphenyl)-4-methyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pent-1-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₄₂B₂O₃

: 78-84-2
isobutyraldehyde

: 1346261-54-8
1-(4-methoxyphenyl)-4-methyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pent-1-en-3-ol

Guidance literature:: C₂₇H₄₂B₂O₃; With dimethyl zinc(II); In toluene; at -78 ℃; for 0.5h; Inert atmosphere;

isobutyraldehyde; In toluene; at -10 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol202588g

Reference yield:

: 872356-95-1
2-[((4-methoxyphenyl)ethynyl)]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

: 1346261-54-8
1-(4-methoxyphenyl)-4-methyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pent-1-en-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 0.5 h / 20 °C / Inert atmosphere

2.1: dimethyl zinc(II) / toluene / 0.5 h / -78 °C / Inert atmosphere

2.2: 12 h / -10 °C / Inert atmosphere

With dimethyl zinc(II); In toluene;
DOI:10.1021/ol202588g

Reference yield: 69.0%

: 1346261-54-8
1-(4-methoxyphenyl)-4-methyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pent-1-en-3-ol

: 1875-48-5
N-aminophthalamide

: 2-(2-(1-hydroxy-2-methylpropyl)-3-(4-methoxyphenyl)-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)aziridin-1-yl)isoindoline-1,3-dione

Guidance literature:: With [bis(acetoxy)iodo]benzene; potassium carbonate; In dichloromethane; at 0 - 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol202588g