6-chloro-3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one

Base Information

Chemical Name:6-chloro-3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
CAS No.:422527-27-3
Molecular Formula:C₁₈H₁₇ClN₂O₃S
Molecular Weight:376.864
Hs Code.:

Synonyms:6-chloro-3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one

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Chemical Property of 6-chloro-3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one

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Technology Process of 6-chloro-3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one

There total 3 articles about 6-chloro-3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 4743-17-3
5-Chloroisatoic anhydride

: 333-20-0
potassium thioacyanate

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 422527-27-3
6-chloro-3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one

Guidance literature:: 5-Chloroisatoic anhydride; 2-(3,4-dimethoxyphenyl)-ethylamine; In water; at 20 ℃; for 1h; Green chemistry;

potassium thioacyanate; With acetic acid; In water; for 3h; Heating; Green chemistry;
DOI:10.1080/17415993.2017.1325891

Reference yield:

: 75-15-0,12122-00-8
carbon disulfide

: 4943-80-0
C₁₇H₁₉ClN₂O₃

: 422527-27-3
6-chloro-3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one

Guidance literature:: With potassium hydroxide; In ethanol; for 3h; Reflux;
DOI:10.1007/s00706-013-1110-8

Reference yield:

: 4743-17-3
5-Chloroisatoic anhydride

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 422527-27-3
6-chloro-3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 3 h / Reflux

2: potassium hydroxide / ethanol / 3 h / Reflux

With potassium hydroxide; In ethanol;
DOI:10.1007/s00706-013-1110-8