phenyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

Base Information

Chemical Name:phenyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate
CAS No.:1415230-93-1
Molecular Formula:C₂₁H₁₉ClN₂O₄
Molecular Weight:398.846
Hs Code.:

Synonyms:phenyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

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Chemical Property of phenyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

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Technology Process of phenyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

There total 3 articles about phenyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 937-41-7
phenyl acrylate

: 1412907-25-5
1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-yl acetate

: 1415230-93-1
phenyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

: 1415231-09-2
diphenyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2012.09.096

Reference yield:

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1415230-93-1
phenyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

: 1415231-09-2
diphenyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 24 h / 60 °C / Reflux

2: 12 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; 3: |Michael Addition;
DOI:10.1016/j.tetlet.2012.09.096

Reference yield:

: 13024-90-3
1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one

: 1415230-93-1
phenyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

: 1415231-09-2
diphenyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 12 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; 2: |Michael Addition;
DOI:10.1016/j.tetlet.2012.09.096