diethyl (4β,5α)-16-oxo-16-{[(1-phenylcyclohexyl)methyl]amino}podocarpa-8,11,13-trien-12-yl phosphate

Base Information

Chemical Name:diethyl (4β,5α)-16-oxo-16-{[(1-phenylcyclohexyl)methyl]amino}podocarpa-8,11,13-trien-12-yl phosphate
CAS No.:551944-37-7
Molecular Formula:C₃₄H₄₈NO₅P
Molecular Weight:581.733
Hs Code.:

Synonyms:diethyl (4β,5α)-16-oxo-16-{[(1-phenylcyclohexyl)methyl]amino}podocarpa-8,11,13-trien-12-yl phosphate

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Chemical Property of diethyl (4β,5α)-16-oxo-16-{[(1-phenylcyclohexyl)methyl]amino}podocarpa-8,11,13-trien-12-yl phosphate

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Technology Process of diethyl (4β,5α)-16-oxo-16-{[(1-phenylcyclohexyl)methyl]amino}podocarpa-8,11,13-trien-12-yl phosphate

There total 3 articles about diethyl (4β,5α)-16-oxo-16-{[(1-phenylcyclohexyl)methyl]amino}podocarpa-8,11,13-trien-12-yl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 551944-07-1
(4β,5α)-12-Hydroxy-N-[(1-phenylcyclohexyl)methyl]podocarpa-8,11,13-trien-16-amide

: 814-49-3
diethyl chlorophosphate

: 551944-37-7
diethyl (4β,5α)-16-oxo-16-{[(1-phenylcyclohexyl)methyl]amino}podocarpa-8,11,13-trien-12-yl phosphate

Guidance literature:: With sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.06.100

Reference yield:

: 5947-49-9
podocarpic acid

: 551944-37-7
diethyl (4β,5α)-16-oxo-16-{[(1-phenylcyclohexyl)methyl]amino}podocarpa-8,11,13-trien-12-yl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: HOBt; EDAC / CH₂Cl₂

2: NaH / tetrahydrofuran

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.06.100

Reference yield:

: 17380-54-0
1-amino-2-phenyl-2,2-pentamethyleneethane

: 551944-37-7
diethyl (4β,5α)-16-oxo-16-{[(1-phenylcyclohexyl)methyl]amino}podocarpa-8,11,13-trien-12-yl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: HOBt; EDAC / CH₂Cl₂

2: NaH / tetrahydrofuran

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.06.100