Technology Process of 2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yloxy)ethanol
There total 7 articles about 2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yloxy)ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol; bis(pinacol)diborane;
With
potassium acetate;
In
dimethyl sulfoxide;
for 0.5h;
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
at 70 ℃;
for 20h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / water; dimethyl sulfoxide / 4 h / 100 °C
2.1: hydrogen; palladium 10% on activated carbon / 20 °C
3.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C
3.2: 2 h / Reflux
4.1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 17 h / 0 - 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -10 °C / Inert atmosphere
6.1: potassium acetate / dimethyl sulfoxide / 0.5 h
6.2: 20 h / 70 °C / Inert atmosphere
With
lithium aluminium tetrahydride; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen bromide; hydrogen; potassium acetate; potassium carbonate; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; water; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / water; dimethyl sulfoxide / 4 h / 100 °C
2.1: hydrogen; palladium 10% on activated carbon / 20 °C
3.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C
3.2: 2 h / Reflux
4.1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 17 h / 0 - 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -10 °C / Inert atmosphere
6.1: potassium acetate / dimethyl sulfoxide / 0.5 h
6.2: 20 h / 70 °C / Inert atmosphere
With
lithium aluminium tetrahydride; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen bromide; hydrogen; potassium acetate; potassium carbonate; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; water; dimethyl sulfoxide; toluene;
