2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol

Base Information

• Chemical Name: 2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol
• CAS No.: 1415794-28-3
• Molecular Formula: C₁₃H₁₈BrNO₂
• Molecular Weight: 300.195
• Mol file: 1415794-28-3.mol

Synonyms:2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol

Chemical Property of 2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol

There total 6 articles about 2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(1-(4-bromophenyl)piperidin-4-yloxy)acetate (1415794-27-2) → 2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol (1415794-28-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -10 ℃; for 2h; Inert atmosphere;

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol (1415794-28-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / water; dimethyl sulfoxide / 4 h / 100 °C

2.1: hydrogen; palladium 10% on activated carbon / 20 °C

3.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C

3.2: 2 h / Reflux

4.1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 17 h / 0 - 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -10 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen bromide; hydrogen; potassium carbonate; sodium hydroxide; sodium nitrite; In tetrahydrofuran; water; dimethyl sulfoxide; toluene;

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → 2-(1-(4-bromophenyl)piperidin-4-yloxy)ethanol (1415794-28-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / water; dimethyl sulfoxide / 4 h / 100 °C

2.1: hydrogen; palladium 10% on activated carbon / 20 °C

3.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C

3.2: 2 h / Reflux

4.1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 17 h / 0 - 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -10 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen bromide; hydrogen; potassium carbonate; sodium hydroxide; sodium nitrite; In tetrahydrofuran; water; dimethyl sulfoxide; toluene;

upstream raw materials:

4-Fluoronitrobenzene

4-HYDROXYPIPERIDINE

4-(4-hydroxypiperidin-1-yl)aniline

1-(4-bromophenyl)piperidin-4-ol

Downstream raw materials:

2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yloxy)ethanol