cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide

Base Information

Chemical Name:cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide
CAS No.:1202008-65-8
Molecular Formula:C₂₃H₃₈FNO₂SSi
Molecular Weight:439.71
Hs Code.:

Synonyms:cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide

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Chemical Property of cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide

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Technology Process of cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide

There total 6 articles about cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202008-49-8
cis-4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexanecarbaldehyde

: 146374-27-8
S-tert-butylsulfinimide

: 1202008-65-8
cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide

Guidance literature:: With titanium(IV) tetraethanolate; In tetrahydrofuran; for 16h; Reflux;

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 1202008-65-8
cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / tetrahydrofuran; methanol / 20 - 50 °C

2.1: hydrogenchloride / ethanol; water / 40 h / Reflux

3.1: sodium tetrahydroborate / ethanol / -20 - 20 °C

4.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

5.1: diisobutylaluminium hydride / dichloromethane / 1.33 h / -70 °C

5.2: 2 h / 20 °C

6.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / Reflux

With 2,6-dimethylpyridine; hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; sodium methylate; diisobutylaluminium hydride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

Reference yield:

: 1202006-99-2
(1s,4s)-1-(4-fluorophenyl)-4-hydroxycyclohexanecarbonitrile

: 1202008-65-8
cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 1.33 h / -70 °C

2.2: 2 h / 20 °C

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / Reflux

With 2,6-dimethylpyridine; titanium(IV) tetraethanolate; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;