N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol

Base Information

Chemical Name:N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol
CAS No.:934221-52-0
Molecular Formula:C₃₀H₃₅N₃O₄
Molecular Weight:501.626
Hs Code.:

Synonyms:N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol

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Chemical Property of N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol

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Technology Process of N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol

There total 7 articles about N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 934221-37-1
N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-L-phenylalanol

: 108-24-7
acetic anhydride

: 934221-52-0
N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol

Guidance literature:: With pyridine; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2011.08.001

Reference yield:

: 17847-26-6
4-[(dimethylamino)methyl]benzoic acid hydrochloride

: 934221-52-0
N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.5 h / 0 °C

2.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 20 °C / pH 6 - 7

3.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.5 h / 0 °C

4.1: pyridine / 5 h / 20 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.08.001

Reference yield:

: 99-75-2
4-methyl-benzoic acid methyl ester

: 934221-52-0
N-(N-(4-dimethylaminomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12 h / Reflux; Inert atmosphere

2.1: potassium carbonate; potassium iodide / ethanol / Inert atmosphere

3.1: hydrogenchloride; water

4.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.5 h / 0 °C

5.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

5.2: 20 °C / pH 6 - 7

6.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.5 h / 0 °C

7.1: pyridine / 5 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; potassium carbonate; potassium iodide; sodium hydroxide; isobutyl chloroformate; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.08.001