3-methoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazole-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester

Base Information

• Chemical Name: 3-methoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazole-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester
• CAS No.: 851179-99-2
• Molecular Formula: C₂₅H₂₈N₂O₅
• Molecular Weight: 436.508
• Mol file: 851179-99-2.mol

Synonyms:3-methoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazole-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester

Chemical Property of 3-methoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazole-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazole-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester

There total 11 articles about 3-methoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazole-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyloxyimino-2-(4-hydroxy-benzyl)-butyric acid methyl ester (851180-88-6) + 2-(2-phenyl-5-methyloxazole-4-yl)ethyl methanesulfonate (227029-27-8) → 3-methoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazole-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester (851179-99-2)

Guidance literature:

With caesium carbonate; In acetonitrile; Heating;

DOI:10.1016/j.bmcl.2006.11.050

Reference yield:

2-acetyl-3-(4-hydroxy-phenyl)-acrylic acid methyl ester (157284-83-8) → 3-methoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazole-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester (851179-99-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂ / Pd(OH)2 / methanol; ethyl acetate

2: 90 percent / NaOAc / methanol

3: Cs₂CO₃ / acetonitrile / Heating

With hydrogen; sodium acetate; caesium carbonate; palladium dihydroxide; In methanol; ethyl acetate; acetonitrile;

DOI:10.1016/j.bmcl.2006.11.050

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 3-methoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazole-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester (851179-99-2)

Guidance literature:

Multi-step reaction with 4 steps

1: piperidine; AcOH / benzene / Heating

2: 95 percent / H₂ / Pd(OH)2 / methanol; ethyl acetate

3: 90 percent / NaOAc / methanol

4: Cs₂CO₃ / acetonitrile / Heating

With hydrogen; sodium acetate; caesium carbonate; piperidine; palladium dihydroxide; acetic acid; In methanol; ethyl acetate; acetonitrile; benzene; 1: Knoevenagel reaction;

DOI:10.1016/j.bmcl.2006.11.050

upstream raw materials:

3-methyloxyimino-2-(4-hydroxy-benzyl)-butyric acid methyl ester

2-(2-phenyl-5-methyloxazole-4-yl)ethyl methanesulfonate

2-acetyl-3-(4-hydroxy-phenyl)-acrylic acid methyl ester

methyl 2-(4-hydroxybenzyl)-3-oxobutanoate