157284-83-8

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 59276-27-6 4-(dimethoxymethyl)phenol 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 932025-01-9 3-(4-fluoro-benzyloxyimino)-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester 
• 932025-08-6 3-(2-fluoro-ethoxyimino)-2-(4-{2-[2-(4-fluoro-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-benzyl)-butyric acid methyl ester 
• 932025-07-5 2-(4-{2-[2-(4-fluoro-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-benzyl)-3-propoxyimino-butyric acid methyl ester 
• 932025-06-4 3-ethoxyimino-2-(4-{2-[2-(4-fluoro-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-benzyl)-butyric acid methyl ester 
• 932025-05-3 3-(2-fluoro-ethoxyimino)-2-{4-[2-(4-fluoro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-benzyl}-butyric acid methyl ester 
• 932024-97-0 3-butoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzyl}-butyric acid methyl ester 

Relevant academic research and scientific papers

Design and synthesis of oxime ethers of α-acyl-β-phenylpropanoic acids as PPAR dual agonists

Oxime ethers of α-acyl-β-phenylpropanoic acids were prepared to apply as PPARα and γ dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC50 of 19 and 13 nM in PPARα and γ, respectively. It showed better g

Efficient and recyclable solid acid-catalyzed alkylation of active methylene compound via oxonium intermediate for atom economical synthesis of organic compounds

In the present work, we report the catalytic reaction of active methylene compounds with cyclic enol ethers and aryl acetals through oxonium intermediate under solvent-free conditions using heterogeneous solid acid catalysts. Among studied solid acid catalysts, Amberlyst-15 gave excellent yields (35–85%) of alkylated products. The catalyst showed broader substrate scope, and a recyclable catalytic cost-efficient approach of the alkylation was examined on the different types of cyclic enol ethers and aryl acetal.