3-acetyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-1-phenylpyrazole

Base Information

• Chemical Name: 3-acetyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-1-phenylpyrazole
• CAS No.: 1100744-57-7
• Molecular Formula: C₂₂H₁₈N₄O₂
• Molecular Weight: 370.411
• Mol file: 1100744-57-7.mol

Synonyms:3-acetyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-1-phenylpyrazole

Chemical Property of 3-acetyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-1-phenylpyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-1-phenylpyrazole

There total 2 articles about 3-acetyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-1-phenylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

sodium 3-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-olate + 1-(N-phenylhydrazono)-1-chloropropanone (18440-58-9,1017827-91-6) → 3-acetyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-1-phenylpyrazole (1100744-57-7)

Guidance literature:

With sodium carbonate; at 20 ℃;

DOI:10.3906/kim-1311-12

Reference yield:

4-acetyl-5-methyl-1-phenylpyrazole (6123-63-3) → 3-acetyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-1-phenylpyrazole (1100744-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate

2: sodium carbonate / 20 °C

With sodium methylate; sodium carbonate;

DOI:10.3906/kim-1311-12

Reference yield: 91.0%

3-acetyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-1-phenylpyrazole (1100744-57-7) → 7-methyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-2-phenyl-2H-pyrazolo[3,4-d]pyridazine (1100744-70-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Reflux;

DOI:10.1002/jhet.5570450627

upstream raw materials:

1-(N-phenylhydrazono)-1-chloropropanone

4-acetyl-5-methyl-1-phenylpyrazole

Downstream raw materials:

7-methyl-4-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-2-phenyl-2H-pyrazolo[3,4-d]pyridazine