N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine

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Chemical Name:N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine
CAS No.:1232220-47-1
Molecular Formula:C₃₃H₄₀N₈O₃
Molecular Weight:596.732
Hs Code.:

Synonyms:N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine

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Chemical Property of N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine

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Technology Process of N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine

There total 5 articles about N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₃₄N₈O₃

: 620-23-5
m-tolyl aldehyde

: 1232220-47-1
N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine

Guidance literature:: With acetic acid; In ethanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.036

Reference yield:

: 78583-82-1
3-amino-5-(4-bromophenyl)-1H-pyrazol

: 1232220-47-1
N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium ethanolate / ethanol / 0.83 h / 150 °C / microwave irradiation

1.2: 7 h / Cooling with ice; Reflux

2.1: 1,4-dioxane / 1 h / 1 - 30 °C

3.1: sodium t-butanolate / tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 0.5 h / 90 °C / Inert atmosphere

4.1: acetic acid / ethanol / 1 h / 1 - 30 °C

With sodium ethanolate; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; acetic acid; In 1,4-dioxane; ethanol; toluene;

Reference yield:

: 1232223-32-3
2-(4-bromophenyl)-5-chloro-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidine

: 1232220-47-1
N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate / tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 0.5 h / 90 °C / Inert atmosphere

2: acetic acid / ethanol / 1 h / 1 - 30 °C

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; acetic acid; In ethanol; toluene;