8-[(2,6-difluorophenyl)methoxy]-N-[(2S)-1,3-dihydroxy-3-methylbutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:8-[(2,6-difluorophenyl)methoxy]-N-[(2S)-1,3-dihydroxy-3-methylbutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1609165-24-3
Molecular Formula:C₂₁H₂₃F₂N₃O₄
Molecular Weight:419.428
Hs Code.:

Synonyms:8-[(2,6-difluorophenyl)methoxy]-N-[(2S)-1,3-dihydroxy-3-methylbutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of 8-[(2,6-difluorophenyl)methoxy]-N-[(2S)-1,3-dihydroxy-3-methylbutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of 8-[(2,6-difluorophenyl)methoxy]-N-[(2S)-1,3-dihydroxy-3-methylbutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

There total 6 articles about 8-[(2,6-difluorophenyl)methoxy]-N-[(2S)-1,3-dihydroxy-3-methylbutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1609165-23-2
methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-L-serinate

: 75-16-1
methylmagnesium bromide

: 1609165-24-3
8-[(2,6-difluorophenyl)methoxy]-N-[(2S)-1,3-dihydroxy-3-methylbutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 1609165-24-3
8-[(2,6-difluorophenyl)methoxy]-N-[(2S)-1,3-dihydroxy-3-methylbutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

5.1: tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; water; sodium methylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 85118-00-9
2,6-Difluorobenzyl bromide

: 1609165-24-3
8-[(2,6-difluorophenyl)methoxy]-N-[(2S)-1,3-dihydroxy-3-methylbutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

5.1: tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; water; sodium methylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide;