[5-(2,4-Dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine

Base Information

• Chemical Name: [5-(2,4-Dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine
• CAS No.: 147054-27-1
• Molecular Formula: C₁₆H₁₁Cl₂N₃OS
• Molecular Weight: 364.255

Synonyms:[5-(2,4-Dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine

Chemical Property of [5-(2,4-Dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine

Chemical Property:

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Technology Process of [5-(2,4-Dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine

There total 2 articles about [5-(2,4-Dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methoxy-benzaldehyde (123-11-5) + 5-(2,4-dichloro-phenyl)-[1,3,4]thiadiazol-2-ylamine (28004-63-9) → [5-(2,4-Dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine (147054-27-1)

Guidance literature:

With piperidine; In ethanol; for 2h; Heating;

Reference yield:

2,4 dichlorobenzoic acid (50-84-0) → [5-(2,4-Dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine (147054-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0 °C / Reflux; Inert atmosphere

1.2: pH 8 - 9

2.1: toluene / Inert atmosphere; Reflux

With trichlorophosphate; In toluene;

DOI:10.1080/00397911003707030

Reference yield: 85.0%

Diethyl phosphonate (762-04-9,123-22-8) + [5-(2,4-Dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine (147054-27-1) → C20H22Cl2N3O4PS (1245932-96-0)

Guidance literature:

at 120 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

DOI:10.1080/00397911003707030

upstream raw materials:

4-methoxy-benzaldehyde

5-(2,4-dichloro-phenyl)-[1,3,4]thiadiazol-2-ylamine

2,4 dichlorobenzoic acid

Downstream raw materials:

C₂₀H₂₂Cl₂N₃O₄PS

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