Technology Process of 1,6-dideutero-4-(tert-butyl)-iodobenzene
There total 1 articles about 1,6-dideutero-4-(tert-butyl)-iodobenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-tert-Butylaniline;
With
hydrogen chloride;
In
water-d2;
at 100 ℃;
for 24h;
Inert atmosphere;
With
sodium nitrite;
In
water-d2;
at 0 ℃;
for 0.5h;
Inert atmosphere;
With
potassium iodide;
In
water-d2;
at 0 - 60 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ja401557m
- Guidance literature:
-
1,6-dideutero-4-(tert-butyl)-iodobenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
Inert atmosphere;
With
Trimethyl borate;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
With
ammonium chloride;
In
water;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ja401557m
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
1.3: 2 h / 20 °C / Inert atmosphere
2.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 3 h / 70 °C / Inert atmosphere
3.1: hydrogenchloride; sodium nitrite / water; methanol / 0.33 h / 0 °C / Inert atmosphere
3.2: 0.92 h / 0 - 60 °C / Inert atmosphere
4.1: 4-tert-butylpyridine / tetrahydrofuran / 50 °C / Sealed tube
With
4-tert-butylpyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; potassium carbonate; sodium nitrite;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;
DOI:10.1021/ja401557m
