Technology Process of (2,6-dideutero-4-(tert-butyl)phenyl)boronic acid
There total 2 articles about (2,6-dideutero-4-(tert-butyl)phenyl)boronic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,6-dideutero-4-(tert-butyl)-iodobenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
Inert atmosphere;
With
Trimethyl borate;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
With
ammonium chloride;
In
water;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ja401557m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen chloride / water-d2 / 24 h / 100 °C / Inert atmosphere
1.2: 0.5 h / 0 °C / Inert atmosphere
1.3: 1 h / 0 - 60 °C / Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
2.3: 2 h / 20 °C / Inert atmosphere
With
n-butyllithium; hydrogen chloride;
In
tetrahydrofuran; hexane; water-d2;
DOI:10.1021/ja401557m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 3 h / 70 °C / Inert atmosphere
2.1: hydrogenchloride; sodium nitrite / water; methanol / 0.33 h / 0 °C / Inert atmosphere
2.2: 0.92 h / 0 - 60 °C / Inert atmosphere
3.1: 4-tert-butylpyridine / tetrahydrofuran / 50 °C / Sealed tube
With
4-tert-butylpyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; sodium nitrite;
In
tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/ja401557m
