N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)-pyridin-2-yl]-1H-pyrrole-3-carboxamide mesylate

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Chemical Name:N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)-pyridin-2-yl]-1H-pyrrole-3-carboxamide mesylate
CAS No.:1373145-46-0
Molecular Formula:CH₄O₃S*C₂₇H₂₈F₃N₅O₂
Molecular Weight:607.654
Hs Code.:

Synonyms:N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)-pyridin-2-yl]-1H-pyrrole-3-carboxamide mesylate

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Chemical Property of N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)-pyridin-2-yl]-1H-pyrrole-3-carboxamide mesylate

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Technology Process of N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)-pyridin-2-yl]-1H-pyrrole-3-carboxamide mesylate

There total 4 articles about N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)-pyridin-2-yl]-1H-pyrrole-3-carboxamide mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-75-2,98527-29-8
methanesulfonic acid

: 1373150-91-4
N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1H-pyrrole-3-carboxamide

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1373145-46-0
N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)-pyridin-2-yl]-1H-pyrrole-3-carboxamide mesylate

Guidance literature:: N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1H-pyrrole-3-carboxamide; 2-chloro-5-trifluoromethylpyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

methanesulfonic acid; In methanol; at 20 ℃;

Reference yield:

: 106058-86-0
1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3-carboxylic acid

: 1373145-46-0
N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)-pyridin-2-yl]-1H-pyrrole-3-carboxamide mesylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 1.5 h / 80 °C

1.2: 3.5 h / 0 °C

2.1: sodium hydroxide; water / methanol; tetrahydrofuran / 2.5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.2: 20 °C

With thionyl chloride; water; sodium hydride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1373150-89-0
N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3-carboxamide

: 1373145-46-0
N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)-pyridin-2-yl]-1H-pyrrole-3-carboxamide mesylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / methanol; tetrahydrofuran / 2.5 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2.2: 20 °C

With water; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;