(S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane

Base Information

• Chemical Name: (S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane
• CAS No.: 111280-67-2
• Molecular Formula: C₄₅H₆₄N₄O₉S₄Si
• Molecular Weight: 961.374
• Mol file: 111280-67-2.mol

Synonyms:(S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane

Chemical Property of (S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane

There total 5 articles about (S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C24H38N2O5S2Si (111280-69-4) + Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester (111280-66-1) → (S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane (111280-67-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 24h;

DOI:10.1039/c39870000277

Reference yield:

(5)-(+)(D)-N,N'-Ditosyl-2,4-diamino-butanol (25139-87-1) → (S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane (111280-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 2 h / 20 °C

2: 80 percent / Cs₂CO₃ / dimethylformamide / 24 h / 70 °C

With 1H-imidazole; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1039/c39870000277

Reference yield:

N,N'-ditoluenesulfonyl-1,3-diaminopropane (53364-99-1) → (S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane (111280-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) K₂CO₃; 2.) Et₃N / 1.) DMF, 60 deg C, 24 h; 2.) CH₂Cl₂, 2 h

2: 80 percent / Cs₂CO₃ / dimethylformamide / 24 h / 70 °C

With potassium carbonate; caesium carbonate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1039/c39870000277

upstream raw materials:

C₂₄H₃₈N₂O₅S₂Si

Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester

⁽⁵⁾-(+)(D)-N,N'-Ditosyl-2,4-diamino-butanol

N,N'-ditoluenesulfonyl-1,3-diaminopropane