Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester

Base Information

• Chemical Name: Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester
• CAS No.: 111280-66-1
• Molecular Formula: C₂₃H₃₄N₂O₁₀S₄
• Molecular Weight: 626.794
• Mol file: 111280-66-1.mol

Synonyms:Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester

Chemical Property of Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester

There total 1 articles about Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1,3]-dioxolan-2-one (96-49-1) + N,N'-ditoluenesulfonyl-1,3-diaminopropane (53364-99-1) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester (111280-66-1)

Guidance literature:

With potassium carbonate; triethylamine; Yield given. Multistep reaction; 1.) DMF, 60 deg C, 24 h; 2.) CH₂Cl₂, 2 h;

DOI:10.1039/c39870000277

Reference yield: 80.0%

C24H38N2O5S2Si (111280-69-4) + Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester (111280-66-1) → (S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane (111280-67-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 24h;

DOI:10.1039/c39870000277

Reference yield:

Methanesulfonic acid 2-[{3-[(2-methanesulfonyloxy-ethyl)-(toluene-4-sulfonyl)-amino]-propyl}-(toluene-4-sulfonyl)-amino]-ethyl ester (111280-66-1) → [(S)-1,4,8,11-Tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradec-5-yl]-methanol (111280-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Cs₂CO₃ / dimethylformamide / 24 h / 70 °C

2: n-Bu₄N⁽¹⁺⁾F^(1-) / tetrahydrofuran

With tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/c39870000277

upstream raw materials:

[1,3]-dioxolan-2-one

N,N'-ditoluenesulfonyl-1,3-diaminopropane

methanesulfonyl chloride

Downstream raw materials:

(S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane

[(S)-1,4,8,11-Tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradec-5-yl]-methanol