(1R,2S)-2-(triphenylmethoxy)methyl-1-(N-methoxy-N-methyl)carbamoyl-1-phenylsulfonylcyclopropane

Base Information

Chemical Name:(1R,2S)-2-(triphenylmethoxy)methyl-1-(N-methoxy-N-methyl)carbamoyl-1-phenylsulfonylcyclopropane
CAS No.:1449741-23-4
Molecular Formula:C₃₂H₃₁NO₅S
Molecular Weight:541.668
Hs Code.:

Synonyms:(1R,2S)-2-(triphenylmethoxy)methyl-1-(N-methoxy-N-methyl)carbamoyl-1-phenylsulfonylcyclopropane

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Chemical Property of (1R,2S)-2-(triphenylmethoxy)methyl-1-(N-methoxy-N-methyl)carbamoyl-1-phenylsulfonylcyclopropane

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Technology Process of (1R,2S)-2-(triphenylmethoxy)methyl-1-(N-methoxy-N-methyl)carbamoyl-1-phenylsulfonylcyclopropane

There total 1 articles about (1R,2S)-2-(triphenylmethoxy)methyl-1-(N-methoxy-N-methyl)carbamoyl-1-phenylsulfonylcyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 76-83-5
trityl chloride

: 408348-28-7
(1R,5S)-1-(phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan-2-one

: 1449741-23-4
(1R,2S)-2-(triphenylmethoxy)methyl-1-(N-methoxy-N-methyl)carbamoyl-1-phenylsulfonylcyclopropane

Guidance literature:: N,O-dimethylhydroxylamine*hydrochloride; (1R,5S)-2-oxo-1-phenylsulfonyl-3-oxabicyclo[3.1.0]hexane; With aluminum (III) chloride; triethylamine; In dichloromethane; at 20 ℃; for 5h;

trityl chloride; With pyridine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2013.06.063

Reference yield: 54.0%

: 1449741-23-4
(1R,2S)-2-(triphenylmethoxy)methyl-1-(N-methoxy-N-methyl)carbamoyl-1-phenylsulfonylcyclopropane

: 1449741-21-2
(1R,2R)-2-(triphenylmethoxymethyl)-1-(N-methoxy-N-methyl)carbamoylcycropropane

: 1449741-22-3
(1S,2R)-2-(triphenylmethoxymethyl)-1-(N-methoxy-N-methyl)carbamoylcycropropane

Guidance literature:: With magnesium; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 1.16667h;
DOI:10.1016/j.bmc.2013.06.063

Reference yield:

: 1449741-23-4
(1R,2S)-2-(triphenylmethoxy)methyl-1-(N-methoxy-N-methyl)carbamoyl-1-phenylsulfonylcyclopropane

: 142096-81-9
{(1R,2R)-2-[(trityloxy)methyl]cyclopropyl}methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / methanol; tetrahydrofuran / 1.17 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2.2: 5 h / 20 °C

With lithium aluminium tetrahydride; magnesium; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2013.06.063