{2-[4-(2-Chlorocarbonylmethoxy-ethoxy)-phenoxy]-ethoxy}-acetyl chloride

Base Information

• Chemical Name: {2-[4-(2-Chlorocarbonylmethoxy-ethoxy)-phenoxy]-ethoxy}-acetyl chloride
• CAS No.: 181725-37-1
• Molecular Formula: C₁₄H₁₆Cl₂O₆
• Molecular Weight: 351.183

Synonyms:{2-[4-(2-Chlorocarbonylmethoxy-ethoxy)-phenoxy]-ethoxy}-acetyl chloride

Chemical Property of {2-[4-(2-Chlorocarbonylmethoxy-ethoxy)-phenoxy]-ethoxy}-acetyl chloride

Chemical Property:

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Technology Process of {2-[4-(2-Chlorocarbonylmethoxy-ethoxy)-phenoxy]-ethoxy}-acetyl chloride

There total 2 articles about {2-[4-(2-Chlorocarbonylmethoxy-ethoxy)-phenoxy]-ethoxy}-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

{2-[4-(2-Carboxymethoxy-ethoxy)-phenoxy]-ethoxy}-acetic acid (181725-36-0) → {2-[4-(2-Chlorocarbonylmethoxy-ethoxy)-phenoxy]-ethoxy}-acetyl chloride (181725-37-1)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In benzene; for 16h; Ambient temperature;

DOI:10.1055/s-1996-4319

Reference yield:

1,4-bis(2-hydroxyethoxy)benzene (104-38-1) → {2-[4-(2-Chlorocarbonylmethoxy-ethoxy)-phenoxy]-ethoxy}-acetyl chloride (181725-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) t-BuOK / 1.) t-BuOH, reflux, 1 h, 2.) t-BuOH, reflux, 36 h

2: 100 percent / (COCl)2, DMF / benzene / 16 h / Ambient temperature

With oxalyl dichloride; potassium tert-butylate; N,N-dimethyl-formamide; In benzene;

DOI:10.1055/s-1996-4319

Reference yield: 85.0%

N-[2-(2-Amino-phenoxy)-phenyl]-2-methoxy-acetamide (181725-29-1) + {2-[4-(2-Chlorocarbonylmethoxy-ethoxy)-phenoxy]-ethoxy}-acetyl chloride (181725-37-1) → N-{2-[2-(2-Methoxy-acetylamino)-phenoxy]-phenyl}-2-(2-{4-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-phenoxy}-ethoxy)-acetamide (181725-38-2)

Guidance literature:

With triethylamine; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1055/s-1996-4319

upstream raw materials:

{2-[4-(2-Carboxymethoxy-ethoxy)-phenoxy]-ethoxy}-acetic acid

1,4-bis(2-hydroxyethoxy)benzene

Downstream raw materials:

N-{2-[2-(2-Methoxy-acetylamino)-phenoxy]-phenyl}-2-(2-{4-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-phenoxy}-ethoxy)-acetamide

[2-(4-{2-[5-Chloro-2-(2,4-dichloro-phenoxy)-phenoxycarbonylmethoxy]-ethoxy}phenoxy)-ethoxy]-acetic acid 5-chloro-2-(2,4-dichloro-phenoxy)-phenyl ester

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