tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate

Base Information

Chemical Name:tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate
CAS No.:1415091-08-5
Molecular Formula:C₂₄H₂₄F₅N₅O₃
Molecular Weight:525.478
Hs Code.:

Synonyms:tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate

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Chemical Property of tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate

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Technology Process of tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate

There total 7 articles about tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1415090-15-1
5-[(tert-butoxycarbonylamino)methyl]-2-(difluoromethyl)pyridine-3-carboxylic acid

: [4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]ammonium formate

: 1415091-08-5
tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 60 ℃; for 18h;

Reference yield:

: 711-33-1
4-trifluoromethyl propiophenone

: 1415091-08-5
tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / acetic acid / 20 - 25 °C

2: ethanol / 24 h / Reflux

3: hydrazine hydrate / ethanol / 0.5 h / 125 °C / microwave irradiation

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 60 °C

With hydrazine hydrate; bromine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; acetic acid;

Reference yield:

: 95728-57-7
2-bromo-1-(4-trifluoromethylphenyl)propan-1-one

: 1415091-08-5
tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 24 h / Reflux

2: hydrazine hydrate / ethanol / 0.5 h / 125 °C / microwave irradiation

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 60 °C

With hydrazine hydrate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;