5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Chemical Name:5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one
CAS No.:1622172-89-7
Molecular Formula:C₃₃H₃₁N₅O₆
Molecular Weight:593.639
Hs Code.:

Synonyms:5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Chemical Property of 5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Technology Process of 5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

There total 6 articles about 5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 39828-35-8
2,4-dimethoxybenzoyl chloride

: 1622173-53-8
5-(1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

: 1622172-89-7
5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;

Reference yield:

: 5397-76-2
1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone

: 1622172-89-7
5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

2: dimethyl amine / 16 h / 110 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / 2 h / 100 °C / Sealed tube; Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; In 1,4-dioxane; methanol; dimethyl amine; N,N-dimethyl-formamide;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1622172-89-7
5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3: dimethyl amine / 16 h / 110 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / 2 h / 100 °C / Sealed tube; Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dimethyl amine; N,N-dimethyl-formamide;