(E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate

Base Information

• Chemical Name: (E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate
• CAS No.: 1611462-23-7
• Molecular Formula: C₂₅H₂₇ClO₃
• Molecular Weight: 410.941
• Mol file: 1611462-23-7.mol

Synonyms:(E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate

Chemical Property of (E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate

There total 3 articles about (E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

allyl iodid (556-56-9) + ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate (1611461-94-9) → (E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate (1611462-23-7)

Guidance literature:

ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

allyl iodid; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 17.0833h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201310183

Reference yield:

4-chlorobenzaldehyde (104-88-1) → (E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate (1611462-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium tert-butoxide / tetrahydrofuran / 2 h / 50 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

2.2: 17.08 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

With sodium hydride; lithium tert-butoxide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/anie.201310183

Reference yield:

ethyl 4-phenyl-2-(n-propyl)-2,3-butadienoate (894855-52-8) → (E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate (1611462-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium tert-butoxide / tetrahydrofuran / 2 h / 50 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

2.2: 17.08 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

With sodium hydride; lithium tert-butoxide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/anie.201310183

upstream raw materials:

ethyl 4-phenyl-2-(n-propyl)-2,3-butadienoate

allyl iodid

ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate

4-chlorobenzaldehyde