Technology Process of N-(1-(3-phenyl-1H-indol-2-yl)ethyl)-9H-purin-6-amine
There total 8 articles about N-(1-(3-phenyl-1H-indol-2-yl)ethyl)-9H-purin-6-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(1-(3-phenyl-1-tosyl-1H-indol-2-yl)ethyl)-9H-purin-6-amine;
With
potassium hydroxide;
In
methanol;
at 70 ℃;
for 72h;
With
hydrogenchloride;
In
methanol; water;
pH=1;
With
sodium hydrogencarbonate;
In
methanol; water;
pH=8;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 10 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: diisobutylaluminium hydride / toluene / 0.75 h / -78 - -10 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
3.2: -78 - 20 °C
4.1: diethyl ether; tetrahydrofuran / -78 - 0 °C / Inert atmosphere
5.1: triphenylphosphine; diphenylphosphoranyl azide; di-isopropyl azodicarboxylate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere
6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 56 h / 120 °C / Sealed tube
8.1: potassium hydroxide / methanol / 72 h / 70 °C
8.2: pH 1
8.3: pH 8
With
oxalyl dichloride; di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; hydrogen; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diisobutylaluminium hydride / toluene / 0.75 h / -78 - -10 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
2.2: -78 - 20 °C
3.1: diethyl ether; tetrahydrofuran / -78 - 0 °C / Inert atmosphere
4.1: triphenylphosphine; diphenylphosphoranyl azide; di-isopropyl azodicarboxylate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere
5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 56 h / 120 °C / Sealed tube
7.1: potassium hydroxide / methanol / 72 h / 70 °C
7.2: pH 1
7.3: pH 8
With
oxalyl dichloride; di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; hydrogen; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; ethyl acetate; toluene; butan-1-ol;
