1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-carbaldehyde

Base Information

Chemical Name:1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-carbaldehyde
CAS No.:1312705-18-2
Molecular Formula:C₁₇H₁₂ClF₃N₂O
Molecular Weight:352.743
Hs Code.:

Synonyms:1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-carbaldehyde

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Chemical Property of 1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-carbaldehyde

Chemical Property:

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Technology Process of 1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-carbaldehyde

There total 5 articles about 1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-carbonitrile

: 1312705-18-2
1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-carbaldehyde

Guidance literature:: With formic acid; In water; for 3h; Reflux;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 552331-16-5
5-bromo-3-methyl-1H-indazole

: 1312705-18-2
1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; tetrabutylammomium bromide / tetrahydrofuran / 1 h

2: palladium diacetate; sodium carbonate / N,N-dimethyl acetamide / 3 h / 105 °C / Inert atmosphere

3: formic acid / water / 3 h / Reflux

With formic acid; tetrabutylammomium bromide; palladium diacetate; sodium carbonate; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; water;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 886496-75-9
1-(bromomethyl)-4-chloro-2-(trifluoromethyl)benzene

: 1312705-18-2
1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; tetrabutylammomium bromide / tetrahydrofuran / 1 h

2: palladium diacetate; sodium carbonate / N,N-dimethyl acetamide / 3 h / 105 °C / Inert atmosphere

3: formic acid / water / 3 h / Reflux

With formic acid; tetrabutylammomium bromide; palladium diacetate; sodium carbonate; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; water;
DOI:10.1016/j.ejmech.2017.07.015