[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]aceticacid

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Chemical Name:[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]aceticacid
CAS No.:1351565-63-3
Molecular Formula:C₂₂H₁₅ClF₃N₃O₄S
Molecular Weight:509.893
Hs Code.:

Synonyms:[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]aceticacid

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Chemical Property of [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]aceticacid

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Technology Process of [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]aceticacid

There total 8 articles about [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]aceticacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: C₂₆H₂₃ClF₃N₃O₄S

: 1351565-63-3
[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]aceticacid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 886496-75-9
1-(bromomethyl)-4-chloro-2-(trifluoromethyl)benzene

: 1351565-63-3
[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]aceticacid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide; tetrabutylammomium bromide / tetrahydrofuran / 1 h

2: palladium diacetate; sodium carbonate / N,N-dimethyl acetamide / 3 h / 105 °C / Inert atmosphere

3: formic acid / water / 3 h / Reflux

4: ammonium acetate; acetic acid / 12 h / 110 °C

5: potassium carbonate / N,N-dimethyl-formamide / 60 °C

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With formic acid; ammonium acetate; tetrabutylammomium bromide; palladium diacetate; sodium carbonate; potassium carbonate; acetic acid; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-carbonitrile

: 1351565-63-3
[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]aceticacid

Guidance literature:: Multi-step reaction with 4 steps

1: formic acid / water / 3 h / Reflux

2: ammonium acetate; acetic acid / 12 h / 110 °C

3: potassium carbonate / N,N-dimethyl-formamide / 60 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With formic acid; ammonium acetate; potassium carbonate; acetic acid; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2017.07.015