Methanesulfonic acid 2-iodo-2-((S)-toluene-4-sulfinyl)-ethyl ester

Base Information

• Chemical Name: Methanesulfonic acid 2-iodo-2-((S)-toluene-4-sulfinyl)-ethyl ester
• CAS No.: 195064-64-3
• Molecular Formula: C₁₀H₁₃IO₄S₂
• Molecular Weight: 388.247
• Mol file: 195064-64-3.mol

Synonyms:Methanesulfonic acid 2-iodo-2-((S)-toluene-4-sulfinyl)-ethyl ester

Chemical Property of Methanesulfonic acid 2-iodo-2-((S)-toluene-4-sulfinyl)-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 2-iodo-2-((S)-toluene-4-sulfinyl)-ethyl ester

There total 2 articles about Methanesulfonic acid 2-iodo-2-((S)-toluene-4-sulfinyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanesulfonyl chloride (124-63-0) + 2-Iodo-2-((S)-toluene-4-sulfinyl)-ethanol (195064-63-2) → Methanesulfonic acid 2-iodo-2-((S)-toluene-4-sulfinyl)-ethyl ester (195064-64-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jo970693a

Reference yield:

(R)-p-tolyl vinyl sulfoxide (54828-68-1) → Methanesulfonic acid 2-iodo-2-((S)-toluene-4-sulfinyl)-ethyl ester (195064-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / NIS, H₂O / dimethylsulfoxide / 40 °C

2: 100 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With N-iodo-succinimide; water; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jo970693a

Reference yield:

Methanesulfonic acid 2-iodo-2-((S)-toluene-4-sulfinyl)-ethyl ester (195064-64-3) → (+)-(R)-2-p-toluenesulfinyl-1,3-butadiene (142048-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / DBU / CH₂Cl₂ / 0.33 h / Ambient temperature

2: 70 percent / Pd(CH₃CN)2Cl₂, 2,6-di-tert-butyl-4-methylphenol / dimethylformamide / 2 h / Ambient temperature

With dichloro bis(acetonitrile) palladium(II); 2,6-di-tert-butyl-4-methyl-phenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo970693a

upstream raw materials:

methanesulfonyl chloride

2-Iodo-2-((S)-toluene-4-sulfinyl)-ethanol

(R)-p-tolyl vinyl sulfoxide

Downstream raw materials:

(+)-(R)-2-p-toluenesulfinyl-1,3-butadiene