2,5-Piperazinedione, 3-(hydroxymethyl)- (6CI,7CI,9CI)

Base Information

• Chemical Name: 2,5-Piperazinedione, 3-(hydroxymethyl)- (6CI,7CI,9CI)
• CAS No.: 89181-64-6
• Molecular Formula: C5H8 N2 O3
• Molecular Weight: 144.13
• Hs Code.: 2933599090
• Mol file: 89181-64-6.mol

Synonyms:2,5-Piperazinedione, 3-(hydroxymethyl)- (6CI,7CI,9CI)

Chemical Property of 2,5-Piperazinedione, 3-(hydroxymethyl)- (6CI,7CI,9CI)

Chemical Property:

• PSA: 78.43000
• LogP: -1.74910

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Piperazinedione, 3-(hydroxymethyl)- (6CI,7CI,9CI)

There total 4 articles about 2,5-Piperazinedione, 3-(hydroxymethyl)- (6CI,7CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C16H27N3O5 → 3-hydroxymethyl-2,5-diketopiperazine (89181-64-6,52661-98-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/ejoc.202001671

Reference yield:

N-glycylserine (687-38-7,82660-87-5) → 3-hydroxymethyl-2,5-diketopiperazine (89181-64-6,52661-98-0)

Guidance literature:

With hydrogenchloride; methanol; beim Eintragen des Methylesters in methylalkoholisches Ammoniak unter Kuehlen;

Reference yield:

N-chloroacetyl-DL-serine (67206-28-4) → 3-hydroxymethyl-2,5-diketopiperazine (89181-64-6,52661-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: water; ammonia / 25 °C

2: methanol; hydrogen chloride / beim Eintragen des Methylesters in methylalkoholisches Ammoniak unter Kuehlen

With hydrogenchloride; methanol; ammonia; water;

upstream raw materials:

N-glycylserine

N-chloroacetyl-DL-serine

Downstream raw materials:

serin

glycine