(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate

Base Information

Chemical Name:(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate
CAS No.:638204-58-7
Molecular Formula:C₁₆H₂₁N₅O₆
Molecular Weight:379.373
Hs Code.:

Synonyms:(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate

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Chemical Property of (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate

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Technology Process of (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate

There total 6 articles about (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 638204-56-5
(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate

: 638204-58-7
(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 5 ℃; for 0.5h;
DOI:10.1021/jm030308b

Reference yield:

: 18226-17-0
N,N-bis(2-hydroxyethyl)-4-nitroaniline

: 638204-58-7
(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / imidazole / dimethylformamide / 48 h / 20 °C

2: H₂ / Pd/C / ethyl acetate; ethanol / 0.5 h / 3102.89 Torr

3: 82 percent / pyridine / tetrahydrofuran / 16 h / 20 °C

4: 82 percent / TBAF / tetrahydrofuran / 0.5 h / 5 °C

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm030308b

Reference yield:

: 304015-61-0
N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-4-nitroaniline

: 638204-58-7
(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethyl acetate; ethanol / 0.5 h / 3102.89 Torr

2: 82 percent / pyridine / tetrahydrofuran / 16 h / 20 °C

3: 82 percent / TBAF / tetrahydrofuran / 0.5 h / 5 °C

With pyridine; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1021/jm030308b