(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate

Base Information

• Chemical Name: (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate
• CAS No.: 638204-56-5
• Molecular Formula: C₂₈H₄₉N₅O₆Si₂
• Molecular Weight: 607.898

Synonyms:(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate

Chemical Property of (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate

Chemical Property:

Purity/Quality:

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Technology Process of (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate

There total 5 articles about (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-nitrophenyl carbonate (263159-60-0) + N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-1,4-benzenediamine (304015-62-1) → (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate (638204-56-5)

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm030308b

Reference yield:

N,N-bis(2-hydroxyethyl)-4-nitroaniline (18226-17-0) → (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate (638204-56-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / imidazole / dimethylformamide / 48 h / 20 °C

2: H₂ / Pd/C / ethyl acetate; ethanol / 0.5 h / 3102.89 Torr

3: 82 percent / pyridine / tetrahydrofuran / 16 h / 20 °C

With pyridine; 1H-imidazole; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm030308b

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)amino]phenylcarbamate (638204-56-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / imidazole / dimethylformamide / 48 h / 20 °C

2: H₂ / Pd/C / ethyl acetate; ethanol / 0.5 h / 3102.89 Torr

3: 82 percent / pyridine / tetrahydrofuran / 16 h / 20 °C

With pyridine; 1H-imidazole; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm030308b

upstream raw materials:

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-nitrophenyl carbonate

N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-1,4-benzenediamine

N,N-bis(2-hydroxyethyl)-4-nitroaniline

tert-butyldimethylsilyl chloride

Downstream raw materials:

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-[bis(2-hydroxyethyl)amino]phenylcarbamate

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