N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide

Base Information

Chemical Name:N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide
CAS No.:126257-68-9
Molecular Formula:C₃₁H₄₂ClN₅O₁₀S₂
Molecular Weight:744.287
Hs Code.:

N-<N'-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide

Synonyms:N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide

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Chemical Property of N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide

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Technology Process of N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide

There total 3 articles about N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126257-65-6
(4R)-N-(carbobenzyloxy)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

: 126257-68-9
N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 2.49 g / H₂, Et₃N / 10percent Pd/C / 3 h / 2068.6 Torr

2: 1.) 1,1-carbonyldiimidazole / 1.) CH₂Cl₂, from 0 to 5 deg C, 30 min, 2.) 25 deg C, overnight

3: camphorosulfonic acid / ethanol / 48 h / 25 °C

With camphor-10-sulfonic acid; hydrogen; triethylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00168a013

Reference yield:

: 121-30-2
chloraminophenamide

: 126257-67-8
N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

: 126257-68-9
N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide

Guidance literature:: With camphor-10-sulfonic acid; In ethanol; at 25 ℃; for 48h;
DOI:10.1021/jm00168a013

Reference yield:

: 126257-66-7
(2S,4R)-4-(2-[1,3]Dioxolan-2-yl-ethoxy)-pyrrolidine-2-carboxylic acid ethyl ester

: 126257-68-9
N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1,1-carbonyldiimidazole / 1.) CH₂Cl₂, from 0 to 5 deg C, 30 min, 2.) 25 deg C, overnight

2: camphorosulfonic acid / ethanol / 48 h / 25 °C

With camphor-10-sulfonic acid; 1,1'-carbonyldiimidazole; In ethanol;
DOI:10.1021/jm00168a013