6-PHENYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Base Information

• Chemical Name: 6-PHENYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
• CAS No.: 885275-13-8
• Molecular Formula: C₁₇H₂₃NO₄
• Molecular Weight: 305.374
• Mol file: 885275-13-8.mol

Synonyms:6-PHENYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Chemical Property of 6-PHENYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Chemical Property:

• PSA: 66.84000
• LogP: 3.39730
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Phenyl-piperidine-1,3-dicarboxylicacid1-tert-butylester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-PHENYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

There total 6 articles about 6-PHENYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H25NO4 (1268249-93-9) → C17H23NO4 (885275-13-8)

Guidance literature:

With water; sodium methylate; In methanol; at 60 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ja111540g

Reference yield:

methyl 3-pyridinecarboxylate (93-60-7) → C17H23NO4 (885275-13-8)

Guidance literature:

Multi-step reaction with 6 steps

1: isopropyl alcohol / 18 h / 20 °C / Inert atmosphere

2: Rh(acac)2(CH₂CH₂)2; sodium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 1,4-dioxane; water / 60 °C / Inert atmosphere

3: 20 % Pd(OH)2/C; hydrogen / ethanol / 18 h / 2327.23 Torr

4: sodium cyanoborohydride / methanol; acetic acid / 3 h / 20 °C / Inert atmosphere

5: 20 % Pd(OH)2/C; hydrogen; triethylamine / ethanol / 18 h / 2327.23 Torr / Inert atmosphere

6: water; sodium methylate / methanol / 18 h / 60 °C / Inert atmosphere

With Rh(acac)2(CH₂CH₂)2; 20 % Pd(OH)2/C; water; hydrogen; sodium methylate; sodium cyanoborohydride; sodium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; In 1,4-dioxane; methanol; ethanol; water; acetic acid; isopropyl alcohol;

DOI:10.1021/ja111540g

Reference yield:

1-benzyl-3-(methoxycarbonyl)pyridinium bromide (6516-41-2) → C17H23NO4 (885275-13-8)

Guidance literature:

Multi-step reaction with 5 steps

1: Rh(acac)2(CH₂CH₂)2; sodium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 1,4-dioxane; water / 60 °C / Inert atmosphere

2: 20 % Pd(OH)2/C; hydrogen / ethanol / 18 h / 2327.23 Torr

3: sodium cyanoborohydride / methanol; acetic acid / 3 h / 20 °C / Inert atmosphere

4: 20 % Pd(OH)2/C; hydrogen; triethylamine / ethanol / 18 h / 2327.23 Torr / Inert atmosphere

5: water; sodium methylate / methanol / 18 h / 60 °C / Inert atmosphere

With Rh(acac)2(CH₂CH₂)2; 20 % Pd(OH)2/C; water; hydrogen; sodium methylate; sodium cyanoborohydride; sodium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; In 1,4-dioxane; methanol; ethanol; water; acetic acid;

DOI:10.1021/ja111540g

upstream raw materials:

methyl 3-pyridinecarboxylate

C₂₀H₂₁NO₂

C₂₀H₂₃NO₂

C₁₈H₂₅NO₄

Downstream raw materials:

(3R, 6R)-1-(tert-butoxycarbonyl)-6-phenylpiperidine-3-carboxylic acid 1-(4-chlorophenyl)methaneamine

Refernces