tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate

Base Information

Chemical Name:tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate
CAS No.:1429228-69-2
Molecular Formula:C₁₆H₂₂N₂O₄
Molecular Weight:306.362
Hs Code.:

Synonyms:tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate

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Chemical Property of tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate

Chemical Property:

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Technology Process of tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate

There total 12 articles about tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1429228-68-1
tert-butyl (3R)-3-(4-formylphenyl)morpholine-4-carboxylate

: 1429228-69-2
tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate

Guidance literature:: With hydroxylamine; In ethanol; at 20 ℃; for 1h;

Reference yield:

: 138713-44-7,74572-03-5
3-(-)-Phenyl morpholine

: 1429228-69-2
tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / 0.5 h / 30 °C

2: [bis-(trifluoroacetoxy)iodo]benzene; iodine / dichloromethane / 0.5 h / 20 °C

3: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; carbon monoxide / methanol / 18 h / 65 °C / Cooling with ice

4: lithium borohydride / tetrahydrofuran-d8 / Reflux

5: manganese(IV) oxide / tetrahydrofuran / 20 °C

6: hydroxylamine / ethanol / 1 h / 20 °C

With manganese(IV) oxide; lithium borohydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; carbon monoxide; [bis-(trifluoroacetoxy)iodo]benzene; hydroxylamine; iodine; triethylamine; In tetrahydrofuran; methanol; tetrahydrofuran-d8; ethanol; dichloromethane;

Reference yield:

: 1429228-66-9
tert-butyl (3R)-3-(4-methoxycarbonylphenyl)morpholine-4-carboxylate

: 1429228-69-2
tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran-d8 / Reflux

2: manganese(IV) oxide / tetrahydrofuran / 20 °C

3: hydroxylamine / ethanol / 1 h / 20 °C

With manganese(IV) oxide; lithium borohydride; hydroxylamine; In tetrahydrofuran; tetrahydrofuran-d8; ethanol;