Benzeneacetyl bromide, alpha-oxo- (9CI)

Base Information

• Chemical Name: Benzeneacetyl bromide, alpha-oxo- (9CI)
• CAS No.: 89177-96-8
• Molecular Formula: C8H5 Br O2
• Molecular Weight: 213.0281
• Hs Code.: 2918300090
• Mol file: 89177-96-8.mol

Synonyms:Glyoxylylbromide, phenyl- (3CI)

Chemical Property of Benzeneacetyl bromide, alpha-oxo- (9CI)

Chemical Property:

• PSA: 34.14000
• LogP: 1.79080

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetyl bromide, alpha-oxo- (9CI)

There total 1 articles about Benzeneacetyl bromide, alpha-oxo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

α-bromoacetophenone (70-11-1) → 2-oxo-2-phenylacetyl bromide (89177-96-8)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 120 ℃; for 0.05h; Microwave irradiation;

DOI:10.1002/jhet.1557

Reference yield: 93.0%

2-oxo-2-phenylacetyl bromide (89177-96-8) + 2-amino-benzenethiol (137-07-5) → 3-phenyl-2H-benzo[b][1,4]thiazin-2-one (33795-58-3)

Guidance literature:

In dimethyl sulfoxide; acetonitrile; at 30 ℃;

DOI:10.3987/COM-21-14460

Reference yield: 89.0%

2-oxo-2-phenylacetyl bromide (89177-96-8) + 1,2-diamino-benzene (95-54-5) → 3-phenylquinoxaline-2(1H)-one (1504-78-5)

Guidance literature:

at 20 ℃;

DOI:10.1002/jhet.1557

upstream raw materials:

α-bromoacetophenone

Downstream raw materials:

trans-Pd(COPh)(Br)(PMePh₂)2

3-phenylquinoxaline-2(1H)-one

3-phenyl-2H-benzo[b][1,4]thiazin-2-one

3-phenyl-1,4-benzoxazin-2-one

Refernces

• 1、 Nagaraj, Muthupandi,Sathiyamoorthy, Sithuraj,Boominathan, Muthusamy,Muthusubramanian, Shanmugam,Bhuvanesh, Nattamai. "An efficient synthetic protocol for quinoxalinones, Benzoxazinones, and benzothiazinones from 2-oxo-2-aryl-acetyl bromide precursors". . p. 1146 - 1151. Retrieved 2013/10/21.