33795-58-3Relevant academic research and scientific papers
An efficient synthetic protocol for quinoxalinones, Benzoxazinones, and benzothiazinones from 2-oxo-2-aryl-acetyl bromide precursors
Nagaraj, Muthupandi,Sathiyamoorthy, Sithuraj,Boominathan, Muthusamy,Muthusubramanian, Shanmugam,Bhuvanesh, Nattamai
, p. 1146 - 1151 (2013)
α-Bromoketones undergo selenium dioxide oxidation to yield reactive 2-oxo-2-arylacetyl bromides that are trapped by aryl-1,2-diamines, 1,2-aminophenol or 1,2-aminothiophenol to give quinoxalinones, benzoxazinones, and benzothiazinones, respectively, in go
Metal-free sp3 C-H bond oxidation and functionalization of α-bromoketones to quinoxalinone, benzoxazinone, and benzothiazinone heterocyclic compounds
Chen, Xiuling,Guo, Fang,Qi, Hongxue,Tian, Haiying,Wei, Tianlong
, p. 1138 - 1148 (2021/06/21)
A series of heterocyclic compounds (benzothiazinones, benzoxazinones and quinoxalinones) were efficiently synthesized in excellent yields via α-bromoketones with o-substituted aniline (2-aminothiophenol, aryl-1,2-diamines and 2-aminophenol). This protocol accomplishes sp3 C-H bond oxidation and functionalization in one-pot without any metal catalyst.
Catalyst free synthesis of 2-Aryl-2H-benzo[b][1,4]oxazines and 3-Aryl-2H-benzo[b][1,4]thiazin-2-ones: An ultrasonication-assisted strategy
Teli, Bisma,Waseem, Malik Abdul,Rashid, Showkat,Ganaie, Bilal Ahmad,Bhat, Bilal A.
supporting information, p. 1541 - 1545 (2021/04/21)
An ultrasonication-assisted synthesis of 2-Aryl-2H-benzo[b][1,4]oxazines and 3-aryl-2H-benzo[b][1,4]thiazin-2-ones has been established by reacting phenacyl bromides with 2-aminophenol and 2-aminothiophenol, respectively. This approach fosters flexibility in generating a diverse range of 1,4-benzoxazines and 1,4-benzothiazinones under catalyst-free reaction conditions. Further scope toward the synthesis of rarely occurring bis-benzoxazine adduct has also been explored, which enabled us to propose the reaction mechanism.
AIBN-Promoted Synthesis of Bibenzo[ b][1,4]thiazines by the Condensation of 2,2′-Dithiodianiline with Methyl Aryl Ketones
Huang, Xianqiang,Rong, Nianxin,Li, Pengfei,Shen, Guodong,Li, Qiang,Xin, Nana,Cui, Chuansheng,Cui, Jichui,Yang, Bingchuan,Li, Dacheng,Zhao, Changqiu,Dou, Jianmin,Wang, Bo
, p. 3332 - 3336 (2018/06/11)
A series of bibenzo[b][1,4]thiazines with various functional groups has been synthesized by a free-radical condensation reaction. Bibenzo[b][1,4]thiazines were obtained in moderate to good yield (up to 85%) through a one-step reaction of readily available 2,2′-dithiodianiline and methyl aryl ketones with AIBN as radical initiator in HOAc. Bibenzo[b][1,4]thiazines exhibit diversiform solid-state packing.
[Ir(P-OP)]-catalyzed asymmetric hydrogenation of diversely substituted C=N-containing heterocycles
Nunez-Rico, Jose Luis,Vidal-Ferran, Anton
, p. 2066 - 2069 (2013/06/04)
Iridium(I) complexes of enantiomerically pure phosphine-phosphite ligands ([Ir(Cl)(cod)(P - OP)]) efficiently catalyze the enantioselective hydrogenation of diverse C=N-containing heterocyclic compounds (benzoxazines, benzoxazinones, benzothiazinones, and quinoxalinones; 25 examples, up to 99% ee). A substrate-to-catalyst ratio as high as 2000:1 was reached.
