2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid

Base Information

Chemical Name:2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid
CAS No.:212769-26-1
Molecular Formula:C₂₄H₃₃NO₆S
Molecular Weight:463.595
Hs Code.:

Synonyms:2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid

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Chemical Property of 2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid

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Technology Process of 2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid

There total 6 articles about 2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 212769-25-0
2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid ethyl ester

: 212769-26-1
2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃;
DOI:10.1021/jm0205548

Reference yield:

: 30512-68-6
2-(4-hydroxy-phenylsulfanyl)-propionic acid ethyl ester

: 212769-26-1
2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / 18-crown-6; K₂CO₃ / acetone / 8 h / Heating

2: aq. Oxone / methanol; tetrahydrofuran / 20 °C

3: 80 percent / 18-crown-6; K₂CO₃ / acetone / Heating

4: 80 percent / aq. NaOH / methanol / 20 °C

With Oxone; sodium hydroxide; 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jm0205548

Reference yield:

: 637-89-8
4-sulfanylphenol

: 212769-26-1
2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diethyl amino-ethoxy)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Et₃N / acetone; CHCl₃ / 1 h / Heating

2: 98 percent / 18-crown-6; K₂CO₃ / acetone / 8 h / Heating

3: aq. Oxone / methanol; tetrahydrofuran / 20 °C

4: 80 percent / 18-crown-6; K₂CO₃ / acetone / Heating

5: 80 percent / aq. NaOH / methanol / 20 °C

With Oxone; sodium hydroxide; 18-crown-6 ether; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; chloroform; acetone;
DOI:10.1021/jm0205548